Semaglutide is a GLP-1 receptor agonist and one of the longest and most thoroughly studied peptides in its class — originally developed for diabetes research.
How does Semaglutide work?
Insulin secretion
Stimulates glucose-dependent insulin release from pancreatic beta cells.
Glucagon suppression
Suppresses glucagon release, additionally stabilising blood sugar.
Gastric emptying
Slows gastric emptying.
CNS effect
Acts on hypothalamic receptors involved in regulating hunger and satiety signalling.
Research status
Semaglutide is approved and is one of the longest-available and best-documented compounds in its class.
Scientific sources
- Wilding JPH, et al.: “Once-Weekly Semaglutide in Adults with Overweight or Obesity” (STEP 1). N Engl J Med. 2021. PubMed (PMID 34192448)
- Study registration: ClinicalTrials.gov, NCT03548935
Semaglutide in comparison
Semaglutide has been available the longest of the three compounds and is documented accordingly. Tirzepatide and Retatrutide represent newer compound classes with less long-term data so far.
Storage & shelf life
Semaglutide ships as a lyophilised powder and stays stable when kept dry, dark and at 2–8°C. After reconstitution with a suitable sterile solvent, keep the solution refrigerated at all times and use within 4 weeks. See our Storage Guide for details.
Semaglutide at Peptid24
Peptid24 carries Semaglutide in 10, 20 and 30 mg — every batch HPLC-verified to ≥98.9% purity, with a Certificate of Analysis (COA).