Semaglutide (brand names Ozempic®, Wegovy®, Rybelsus®) is a GLP-1 receptor agonist and one of the most extensively studied peptides in its class. Originally developed to treat type 2 diabetes, it is now also approved for obesity treatment due to its pronounced weight-reducing effect.
Mechanism of Action
- Insulin secretion: Semaglutide stimulates glucose-dependent insulin release from pancreatic beta cells.
- Glucagon suppression: Suppresses glucagon release, further stabilising blood sugar.
- Gastric emptying: Slows gastric emptying, promoting longer-lasting satiety.
- CNS effect: Acts on hunger and satiety centres in the hypothalamus, durably reducing calorie intake.
Semaglutide has a long half-life of about one week, enabling weekly dosing intervals.
Clinical Studies
The STEP-1 programme (Novo Nordisk, 2021, published in the New England Journal of Medicine) studied Semaglutide 2.4mg over 68 weeks in adults with obesity. Result: an average body weight reduction of 14.9% versus 2.4% in the placebo group.
Semaglutide vs. Tirzepatide vs. Retatrutide
| Peptide | Agonism | Avg. reduction (trial) | Status |
|---|---|---|---|
| Semaglutide | GLP-1 | ~15% (STEP-1) | Approved |
| Tirzepatide | GLP-1, GIP | ~22.5% (SURMOUNT-1) | Approved |
| Retatrutide | GLP-1, GIP, Glucagon | ~24% (TRIUMPH) | Phase 2 |
Semaglutide has been available the longest and is therefore the best documented peptide in this class. Tirzepatide and Retatrutide achieve higher reductions in trials but are newer with less long-term data available.
Storage
Semaglutide is supplied as a lyophilized powder. Storage: dry, protected from light at 2–8°C. After reconstitution with BAC Water keep refrigerated and use within 4 weeks. More in our Storage Guide.
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Peptid24 offers Semaglutide in 5mg and 10mg strengths. Every batch is HPLC-verified at ≥98.9% purity, with COA included. Shipped from Germany.
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Frequently asked questions about Semaglutide — find answers in our FAQ.