Tirzepatide belongs to the compound class known as “twincretins” — peptides that target two hormone receptors at once: GIP and GLP-1. For research, the combination of both pathways in a single molecule is particularly interesting, as it goes beyond a pure GLP-1 effect.
How does Tirzepatide work?
GLP-1 axis
Increases glucose-dependent insulin release, suppresses glucagon and delays gastric emptying — regulates blood sugar.
GIP axis
Further enhances the insulinotropic response, is involved in fat metabolism and improves insulin sensitivity in liver and adipose tissue.
The interplay of both axes is a central focus of current incretin research.
Research status
Tirzepatide is approved and is one of the best-documented dual receptor agonists in current metabolic research.
Scientific sources
- Jastreboff AM, et al.: “Tirzepatide Once Weekly for the Treatment of Obesity” (SURMOUNT-1). N Engl J Med. 2022. PubMed (PMID 35658024)
- Study registration: ClinicalTrials.gov, NCT04184622
Tirzepatide in comparison
Storage & shelf life
Tirzepatide ships as a lyophilised powder and stays stable when kept dry, dark and at 2–8°C. After reconstitution with a suitable sterile solvent, keep the solution refrigerated at all times and use within 4 weeks. See our Storage Guide for details.
Tirzepatide at Peptid24
Peptid24 carries Tirzepatide in 10, 20, 30 and 40 mg — HPLC-verified to ≥98.9% purity, with a batch-specific COA.